Mini-review

Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors

  1. Philip W Miller*

Article first published online: 30 OCT 2008

DOI: 10.1002/jctb.2061

Issue

Journal of Chemical Technology and Biotechnology

Journal of Chemical Technology and Biotechnology

Volume 84, Issue 3, pages 309–315, March 2009

Additional Information

How to Cite

Miller, P. W. (2009), Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors. J. Chem. Technol. Biotechnol., 84: 309–315. doi: 10.1002/jctb.2061

Author Information

  1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK

*Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.

Publication History

  1. Issue published online: 2 FEB 2009
  2. Article first published online: 30 OCT 2008
  3. Manuscript Accepted: 26 AUG 2008
  4. Manuscript Revised: 22 AUG 2008
  5. Manuscript Received: 14 JUL 2008

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Keywords:

  • microfluidic;
  • microreactor;
  • positron emission tomography (PET);
  • radiolabelling;
  • carbon-11;
  • fluorine-18

Abstract

This mini-review covers the issues concerning the application of microfluidics towards radiolabelling with short-lived isotopes used for PET (positron emission tomography), and surveys the literature in this area. The application of microfluidic reactors to radiolabelling reactions is currently receiving a great deal of interest because of the potential advantages they have over conventional labelling systems. The volume and variety of radiolabelling reactions for PET is expected to grow markedly over the coming years due to increased demands for PET scanning. High demands and expectations for radiolabelled compounds will have to be met by exploiting new types of chemistry and technologies, such as microfluidics, to improve the production and development of PET tracers. Copyright © 2008 Society of Chemical Industry

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