Amphibia Kupffer cells
Article first published online: 20 JUN 2002
Copyright © 2002 Wiley-Liss, Inc.
Microscopy Research and Technique
Special Issue: The Biology of Phagocytosis
Volume 57, Issue 6, pages 477–490, 15 June 2002
How to Cite
Sichel, G., Scalia, M. and Corsaro, C. (2002), Amphibia Kupffer cells. Microsc. Res. Tech., 57: 477–490. doi: 10.1002/jemt.10101
- Issue published online: 20 JUN 2002
- Article first published online: 20 JUN 2002
- Manuscript Accepted: 18 JUN 2001
- Manuscript Received: 26 MAR 2001
- Kupffer cells;
Amphibia Kupffer cells (i.e., liver resident macrophages) show many common characteristics when compared with Mammalia Kupffer cells: filopodia, microvillous-like structures, lamellipodia, fuzzy coat, coated vesicles, bristled vacuoles, nonspecific esterase activity, and pinocytotic and phagocytic activity are present both in Amphibia and Mammalia Kupffer cells. On the other hand, some differences are present between Kupffer cells of both zoological classes: phagocytosed red cells and their derivatives, iron–protein complexes, and lipofuscin bodies are normally present in Amphibia Kupffer cells, but absent in the same cells of healthy mammals. Worm-like structures are not seen in Amphibia and endogenous peroxidase activity is very weak in these animals compared with Mammalia. The most important difference lies in the ability of Amphibia Kupffer cells to produce melanins: in fact the tyrosinase gene is expressed, “melanosome centers” are present, and dopa oxidase activity is demonstrable. Microsc. Res. Tech. 57:477–490, 2002. © 2002 Wiley-Liss, Inc.