Hypoxia-induced pathways in breast cancer

Authors

  • T.I. Goonewardene,

    1. Imperial Cancer Research Fund, Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
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  • H.M. Sowter,

    1. Imperial Cancer Research Fund, Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
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  • A.L. Harris

    Corresponding author
    1. Imperial Cancer Research Fund, Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    • ICRF, WIMM, John Radcliffe Hospital, Oxford, OX3 9DS, UK
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Abstract

Hypoxia, a common consequence of solid tumor growth in breast cancer and other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and alterations in microenvironmental pH. Hypoxia-inducible factors, heterodimeric DNA binding complexes composed of two subunits, provide critical regulation of this response. This review presents a synopsis of the genes induced by hypoxia in the context of breast cancer and discusses how upregulation of HIF-1 activity, and the homologous factor HIF-2, are not only fundamental for the adaptation to hypoxia but also may be critical for tumor progression. Microsc. Res. Tech. 59:41–48, 2002. © 2002 Wiley-Liss, Inc.

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