Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes
Article first published online: 4 FEB 2005
Copyright © 1994 Wiley-Liss, Inc.
Microscopy Research and Technique
Volume 28, Issue 6, pages 505–519, 15 August 1994
How to Cite
Hunziker, E. B. (1994), Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc. Res. Tech., 28: 505–519. doi: 10.1002/jemt.1070280606
- Issue published online: 4 FEB 2005
- Article first published online: 4 FEB 2005
- Manuscript Revised: 25 SEP 1993
- Manuscript Accepted: 25 SEP 1993
- Manuscript Received: 15 MAR 1993
- Growth hormone;
- Growth factors;
Growth plate chondrocytes play a pivotal role in promoting longitudinal bone growth. The current review represents a brief survey of the phenomena involved in this process at the cellular level; it delineates the contributions made by various activities during the course of the chondrocyte life cycle, notably proliferation and hypertrophy, and illustrates how the relative contributions may be modulated according to the particular needs of an organism at critical phases of growth. The cellular mechanisms by which a few well characterized growth-promoting substances exert their influences are discussed in the light of recent findings pertaining to epiphyseal plate chondrocytes in vivo. © 1994 Wiley-Liss, Inc.