Spatial organization of cardiac gap junctions can affect access resistance
Article first published online: 4 FEB 2005
Copyright © 1995 Wiley-Liss, Inc.
Microscopy Research and Technique
Volume 31, Issue 5, pages 446–451, 1 August 1995
How to Cite
Hall, J. E. and Gourdie, R. G. (1995), Spatial organization of cardiac gap junctions can affect access resistance. Microsc. Res. Tech., 31: 446–451. doi: 10.1002/jemt.1070310513
- Issue published online: 4 FEB 2005
- Article first published online: 4 FEB 2005
- Manuscript Accepted: 28 SEP 1994
- Manuscript Received: 26 AUG 1993
- Confocal microscopy;
- Gap junction channels;
- Mathematical analytical model
In the heart, gap junctions electrically couple myocytes together. Electron- and light-microscope-based analyses have revealed that cardiac gap junctions show a variety of organizational patterns. At the level of gap-junctional channel aggregates, freeze fracture has demonstrated diverse channel packing arrangements in the membranes of different myocardial tissues. Ultrastructural and immunohistochemical studies have shown variation and specialization in the 3-dimensional spatial distribution of gap junctional contacts between different types of myocardial cells. Here, we estimate the access resistance of various configurations of gap junctions using physical principles and explore how certain of these specializations in gap-junctional organization may influence access resistance, a potentially important determinant of electrical conductance between coupled myocardial cells. © 1995 Wiley-Liss, Inc.