Alveolar macrophage–T cell interactions during Th1-type sarcoid inflammation
Article first published online: 30 APR 2001
Copyright © 2001 Wiley-Liss, Inc.
Microscopy Research and Technique
Special Issue: Cellular and Molecular Basis of Delayed Hypersensitivity in the Lung
Volume 53, Issue 4, pages 278–287, 15 May 2001
How to Cite
Agostini, C., Facco, M., Chilosi, M. and Semenzato, G. (2001), Alveolar macrophage–T cell interactions during Th1-type sarcoid inflammation. Microsc. Res. Tech., 53: 278–287. doi: 10.1002/jemt.1094
- Issue published online: 30 APR 2001
- Article first published online: 30 APR 2001
- Manuscript Accepted: 22 JUN 2000
- Manuscript Received: 7 JUN 2000
- Regione Veneto e Ministero della Sanità, Istituto Superiore della Sanità, Progetto Tubercolosi 1999. Grant Number: 96/D/T42
Sarcoidosis is an immunomediated, multisystem disorder of unknown cause(s) characterized by a heightened Th1 immune response that leads to an uncontrolled granuloma formation at sites of disease activity. The past few years have seen outstanding advances in the understanding of immunological and molecular events involved in the pathogenesis of this disease. The idea is that several cytokines and chemokines, which are secreted at sites of disease activity, participate in granuloma formation. This paper describes recent data that have clarified some of the events that govern the development of the hypersensitivity reaction during sarcoidosis. In particular, we will review recent evidence indicating that a complex relationship exists between the macrophage/lymphocyte cellular axis and the tissue networks of cytokines. Microsc. Res. Tech. 53:278–287, 2001. © 2001 Wiley-Liss, Inc.