Gastric leptin

Authors

  • Miguel J.M. Lewin,

    Corresponding author
    1. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 410; IFR02 Cellules Epithéliales, Faculté de médecine Xavier Bichat, 75018 Paris, France
    • Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 410; IFR02 Cellules Epithéliales, 16 rue Henri Huchard, Faculté de médecine Xavier Bichat, 75018 Paris, France
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  • André Bado

    1. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 410; IFR02 Cellules Epithéliales, Faculté de médecine Xavier Bichat, 75018 Paris, France
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Abstract

The recent discovery of gastric leptin has initiated several investigations on the possible role of leptin in digestive physiology. The following clues are currently suggested: leptin might control meal size in cooperation with Cholecystokinin, help cytoprotection of the gastric mucosa, play a role in gut inflammatory processes, regulate secretion of gastric hormones such as gastrin and somatostatin, and modulate intestinal transport of small peptides. The present review is a brief survey of the most significant advances in these issues. Microsc. Res. Tech. 53:372–376, 2001. © 2001 Wiley-Liss, Inc.

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