References “Bruni et al., 2004,” “Conti et al., 2005,” and “Conti et al., 2007” are part I–III.
Microimaging FTIR of head and neck tumors. IV†
Article first published online: 29 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
Microscopy Research and Technique
Volume 72, Issue 2, pages 67–75, February 2009
How to Cite
Conti, C., Ferraris, P., Garavaglia, M., Giorgini, E., Rubini, C., Sabbatini, S. and Tosi, G. (2009), Microimaging FTIR of head and neck tumors. IV. Microsc. Res. Tech., 72: 67–75. doi: 10.1002/jemt.20644
- Issue published online: 12 JAN 2009
- Article first published online: 29 SEP 2008
- Manuscript Accepted: 18 AUG 2008
- Manuscript Received: 16 MAY 2008
- infrared microspectroscopy;
- pattern recognition analysis;
- cluster analysis;
- salivary glands neoplasia
On continuing our studies on head and neck neoplasia, specimens from salivary gland tumors have been explored by using infrared microimaging spectroscopy to discern healthy from neoplastic tissues. Samples with Warthin tumor, epithelial displasia, marginal B-cell lymphoma, low-grade adenocarcinoma, and adenoid cystic carcinoma pathologies have been investigated by using conventional light sources. Changes were monitored at the molecular level, probing spectral markers such as Amide I and II, phosphate, nucleic acids, and carbohydrates vibrational modes. In all cases, supervised and unsupervised spectral analyses resulted in satisfactory agreement with histopathological findings. Microsc. Res. Tech., 2009. © 2008 Wiley-Liss, Inc.