Miriam Draenert and Alice Draener contributed equaly to this work.
Osseointegration of hydroxyapatite and remodeling-resorption of tricalciumphosphate ceramics
Article first published online: 7 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Microscopy Research and Technique
Volume 76, Issue 4, pages 370–380, April 2013
How to Cite
Draenert, M., Draenert, A. and Draenert, K. (2013), Osseointegration of hydroxyapatite and remodeling-resorption of tricalciumphosphate ceramics. Microsc. Res. Tech., 76: 370–380. doi: 10.1002/jemt.22176
- Issue published online: 23 MAR 2013
- Article first published online: 7 FEB 2013
- Manuscript Accepted: 30 DEC 2012
- Manuscript Received: 5 NOV 2012
- bone remodeling;
Background: Cancellous bone defects surrounded by still intact bone structures never heal. Ceramics offer a solution providing osteoconductive scaffolds. Purpose: The purpose of the study is to evaluate whether structured β-TCP and HA implants can reconstruct cancellous bone defects, which role micro- and macro-porosity, stiffness and surface area play; finally the indication for both materials based on its resorbability. Material & Methods: 10 German Shepard dogs were operated on both tibial heads implanting shell-like fully interconnected ceramic cylinders, using a wet grinding hollow drill coated with diamonds. β-TCP was compared with HA. A polychromatic sequential labelling with 4 different fluorochromes controlled bone formation dynamics. Non-decalcifying histology after perfusion fixation and vessel casting was performed. μ-CT was combined with high resolution microradiography and histology on thin ground crossections. The stages after 6 weeks, 2, 3, 4 months and 15 months were evaluated. Results: In spite of osseointegration of HA and β-TCP, the osseointegration of both materials was completely different. Both shell-like bone void fillers were osseointegrated in a sandwich-like manner. HA yielded primarily a reinforcement of the recipient's cancellous-bone bed and full osseointegration after 4 months, whereas β-TCP-implants were fully osseointegrated after 6 weeks. HA did not show signs of resorption. The resorption of the β-TCP resulted during remodelling. The final stage showed restitution “ad integrum” of the β-TCP defects with a physiological architecture, whereas HA was integrated in the cancellous bone construction providing 600 μm measuring macropores showing osteoinductive properties. Microsc. Res. Tech. 76:370–380, 2013. © 2013 Wiley Periodicals, Inc.