This work was supported by a National Institutes of Health Institutional grant 4314-03 from the University of North Dakota School of Medicine and by University of North Dakota Faculty Research grant 4522-79 from the National Science Foundation.
Response of the adult newt ventricle to injury†
Article first published online: 13 MAY 2005
Copyright © 1974 Wiley-Liss, Inc., A Wiley Company
Journal of Experimental Zoology
Volume 187, Issue 2, pages 249–259, February 1974
How to Cite
Oberpriller, J. O. and Oberpriller, J. C. (1974), Response of the adult newt ventricle to injury. J. Exp. Zool., 187: 249–259. doi: 10.1002/jez.1401870208
- Issue published online: 13 MAY 2005
- Article first published online: 13 MAY 2005
A study was made of the response of adult newt ventricle to injury. The major events in the repair process after wounding involve blood clot formation, coagulation necrosis, macrophagic activity, regenerative activity of heart muscle, and connective tissue formation. Light microscopic autoradiography indicated that there was a definite area of labeled cells in trabeculae adjacent to the wound, beginning at about ten days after injury. Electron microscopic autoradiography confirmed that myocytes containing myofibrillae underwent DNA synthesis. It was concluded that adult newt myocardium is capable of reacting to injury by the proliferation of myocytes at the wound area as indicated by both DNA synthesis and mitosis.