Transformation of amphibian xanthophores into melanophores in clonal culture


  • Hiroyuki Ide

    1. Biological Institute, Faculty of Science, Nagoya University, Nagoya 464, Japan
    Current affiliation:
    1. Department of Cell and Developmental Biology, University of Arizona, Tucson, Arizona 85721
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Xanthophores isolated from bullfrog tadpoles were successfully cloned. The rapid disappearance of the yellow pigment-containing organelles (pterinosomes) occurred in proliferating xanthophores and many black granules were newly synthesized in the cells. The granules were electronmicroscopically identified as melanin granules. These chromatophores showed melanin dispersion by the addition of the alkali-treated ACTH. The findings suggest that xanthophores transform into melanophores in vitro.