Evolution of microRNAs located within Hox gene clusters

Authors

  • Andrea Tanzer,

    Corresponding author
    1. Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, Kreuzstraße 7b, D-04103 Leipzig, Germany
    2. Department of Theoretical Chemistry and Structural Biology, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria
    • Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, Kreuzstraße 7b, D-04103 Leipzig, Germany
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  • Chris T. Amemiya,

    1. Virginia Mason Research Center, Benaroya Research Institute, Molecular Genetics Dept. 1201 Ninth Avenue, Seattle, WA 98101 USA
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  • Chang-Bae Kim,

    1. National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yusong-gu, 305-333 Taejon, Korea
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  • Peter F. Stadler

    1. Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, Kreuzstraße 7b, D-04103 Leipzig, Germany
    2. Department of Theoretical Chemistry and Structural Biology, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria
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Abstract

MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in post-transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. J. Exp. Zool. (Mol. Dev. Evol.) 304B: 1–10, 2005. © 2005 Wiley-Liss, Inc.

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