Jianghong Wu and Husile contributed equally to this work.
Adaptive evolution of Hoxc13 genes in the origin and diversification of the vertebrate integument
Article first published online: 19 JUL 2013
© 2013 Wiley Periodicals, Inc.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume 320, Issue 7, pages 412–419, November 2013
How to Cite
2013. Adaptive evolution of Hoxc13 genes in the origin and diversification of the vertebrate integument. J. Exp. Zool. (Mol. Dev. Evol.) 320B:412–419., , , , , , .
- Issue published online: 7 OCT 2013
- Article first published online: 19 JUL 2013
- Manuscript Accepted: 1 APR 2013
- Manuscript Revised: 7 MAR 2013
- Manuscript Received: 7 NOV 2012
- National Natural Science Foundation of China. Grant Numbers: 31260538, 31260545
- Key Project of National Science and Technology Pillar Program of China. Grant Number: 2011BAD28B05
- Natural Science Foundation of Inner Mongolian. Grant Number: 2013MS0414,2011MS0401
The problem of origination and diversification of integument derivatives in vertebrates is still a challenge. The homeobox (Hox) genes Hoxc13 control integument formation in vertebrate. Hoxc13 show strong expression in the integument development, are highly conserved across vertebrates, and show mutations that are associated with skin and appendages. To test whether the evolution of the integument is associated with positive selection or relaxation of Hoxc13, we obtained these genes in a wide range of vertebrates. In Hoxc13, we found evidence of diversifying selection after speciation during the origin of vertebrates. In addition, we found the glycine-rich regions in Hoxc13 protein in mammals, but not among non-mammalian taxa. Our results strongly implicate that Hoxc13 genes could have played an important role in the evolution of integument structure. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 412–419, 2013. © 2013 Wiley Periodicals, Inc.