Anne Nitsche and Gero Doose are joint first authors.
Atypical RNAs in the coelacanth transcriptome
Article first published online: 30 OCT 2013
© 2013 Wiley Periodicals, Inc.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
Special Issue: Genome of the African Coelacanth
Volume 322, Issue 6, pages 342–351, September 2014
How to Cite
2013. Atypical RNAs in the coelacanth transcriptome. J. Exp. Zool. (Mol. Dev. Evol.) 322B:342–351., , , , , , , , , .
Conflicts of interest: None.
- Issue published online: 6 AUG 2014
- Article first published online: 30 OCT 2013
- Manuscript Accepted: 16 AUG 2013
- Manuscript Revised: 22 JUL 2013
- Manuscript Received: 24 APR 2013
- European Union FP-7 Project QUANTOMICS. Grant Number: 222664
- Federal Ministry of Education and Research in Germany (BMBF) Project ICGC MMML-Seq. Grant Number: 01KU1002J
- Italian Ministry for University and Research. Grant Numbers: UNIVPM6170, UNIVPM6823
Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 342–351, 2014. © 2013 Wiley Periodicals, Inc.