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FilenameFormatSizeDescription
jezb22559-sm-0001-SupFig-S1.tif665KFigure S1. Phylogenetic relationships of coelacanth, mammal, reptile, amphibian, fish, elephant shark, and lamprey tlr genes, based on amino acid sequence alignment of the TIR domains.
jezb22559-sm-0001-SupFig-S2.tif417KFigure S2. Evolutionary relationships of TIR domains for TLR3. See Figure S1 legend for details.
jezb22559-sm-0001-SupFig-S3.tif338KFigure S3. Evolutionary relationships of TIR domains for TLR5. See Figure S1 legend for details.
jezb22559-sm-0001-SupFig-S4.tif604KFigure S4. Evolutionary relationships of TIR domains for TLR7/8/9. See Figure S1 legend for details.
jezb22559-sm-0001-SupFig-S5.tif212KFigure S5. Multiple sequence alignment of HIN200 domains from coelacanth and ALRs from eutherian and metatherian mammals.
jezb22559-sm-0001-SupFig-S6.tif104KFigure S6. Coelacanth IL1B selectively clusters with amphibian and avian species.
jezb22559-sm-0001-SupFig-S7.tif93KFigure S7. Phylogenetic analysis of coelacanth IL18 selectively clusters with avian IL18 within the greater mammalian clade.
jezb22559-sm-0001-SupFig-S8.tif113KFigure S8. Multiple alignment of the coelacanth type I IFN sequences.
jezb22559-sm-0001-SupFig-S9.tif80KFigure S9. Coelacanth type I IFNs selectively cluster with chicken IFNA and B.
jezb22559-sm-0001-SupFig-S10.tif72KFigure S10. Phylogenetic relationships of coelacanth, mammalian, avian (chicken), amphibian (clawed frog), fish (zebrafish, fugu, stickleback, rainbow trout, Atlantic salmon, channel catfish) type I ifnr genes, based on amino acid sequence alignment.
jezb22559-sm-0001-SupFig-S11.tif79KFigure S11. Phylogenetic relationships of coelacanth, human, chicken, amphibian (clawed frog), zebrafish irf genes, based on amino acid sequence alignment.
jezb22559-sm-0001-SupFig-S12.tif84KFigure S12. Phylogenetic relationships of coelacanth, human, chicken, amphibian (clawed frog), zebrafish stat genes, based on amino acid sequence alignment.
jezb22559-sm-0001-SupFig-S13.tif46KFigure S13. Phylogenetic relationships of members of the ISG12/IFI27 family from coelacanth, mammals (human), reptiles (chicken), and fish (zebrafish).
jezb22559-sm-0001-SupTable-S1.docx66KTable S1. Coelacanth tlr genes.
jezb22559-sm-0001-SupTable-S2.docx77KTable S2. Coelacanth TLR accessory molecules.
jezb22559-sm-0001-SupTable-S3.docx157KTable S3. NLRs in Latimeria chalumnae and their expression in L. menadoensis.
jezb22559-sm-0001-SupTable-S4.docx109KTable S4. Class IV trim genes from Latimeria chalumnae.
jezb22559-sm-0001-SupTable-S5.docx85KTable S5. Coelacanth genes from the IFN pathway.
jezb22559-sm-0001-SupTable-S6.docx116KTable S6. Coelacanth members of different ISG families.
jezb22559-sm-0001-SupTable-S7.doc61KTable S7. Coelacanth IgSF molecules with unclear phylogenetic relationships including putative CEACAM, Siglec, DCIP, FcRH, MDIR genes.

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