Gene therapy clinical trials worldwide to 2012 – an update
Article first published online: 27 FEB 2013
Copyright © 2013 John Wiley & Sons, Ltd.
The Journal of Gene Medicine
Volume 15, Issue 2, pages 65–77, February 2013
How to Cite
Ginn, S. L., Alexander, I. E., Edelstein, M. L., Abedi, M. R. and Wixon, J. (2013), Gene therapy clinical trials worldwide to 2012 – an update. J. Gene Med., 15: 65–77. doi: 10.1002/jgm.2698
- Issue published online: 27 FEB 2013
- Article first published online: 27 FEB 2013
- Accepted manuscript online: 28 JAN 2013 01:55AM EST
- clinical trials;
- gene therapy;
- The Journal of Gene Medicine;
To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors.
This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of our June 2012 update, we have entries on 1843 trials undertaken in 31 countries. We have analysed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and which genes have been transferred. Details of the analyses presented, and our searchable database are available on The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: http://www.wiley.co.uk/genmed/clinical. We also provide an overview of the progress being made in clinical trials of gene therapy approaches around the world and discuss the prospects for the future. Copyright © 2013 John Wiley & Sons, Ltd.