Repeated short-term deployments of seismic, infrasound, video, and gas-emission instruments at Fuego volcano, Guatemala have revealed three types of very long period (VLP) events associated with conduit sealing, pressure accumulation, and release. In 2008, ash-rich explosions issued from a vent on the western flank and produced one type of VLP (Type 1). Impulsive, bomb-rich explosions from the summit vent in 2009 produced a shorter period VLP (Type 2), but also generated ash release. Type 3 VLP events occurred during ash-free exhalations from the summit in 2008 and had waveform shapes similar to Type 2 events. Weak infrasound records for Type 1 explosions compared to Type 2 suggest lower pressures and higher magma porosity for Type 1. Type 3 events correlate with spikes in SO2 emission rate and are driven by partial sealing and rapid release of ash-free gas at the summit vent. Variations in the VLP period may provide a new tool for monitoring conditions within the conduit.