The first example of a regioselective Biginelli-like reaction based on 3-alkylthio-5-amino-1,2,4-triazole

Authors

  • Qiong Chen,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
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  • Li-Li Jiang,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
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  • Chao-Nan Chen,

    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
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  • Guang-Fu Yang

    Corresponding author
    1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
    • Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China

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Abstract

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The three-component condensation of 3-amino-5-alkylthio-1,2,4-triazoles with aromatic aldehydes and β-ketoester was studied to develop a regioselective Biginelli-like reaction. The results indicated that the reaction solvent and the properties of the β-ketoester component displayed great influence on the regioselectivity. This is the first report about the regioselectivity of the aminotriazole-based Biginelli-like reaction. J. Heterocyclic Chem., (2009).

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