Piperidine mediated synthesis of n-heterocyclic chalcones and their antibacterial activity

Authors

  • P. Venkatesan,

    Corresponding author
    1. School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625 021, India
    Current affiliation:
    1. Department of Chemistry, Mahendra Institute of Technology, India 637 503
    • School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625 021, India

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  • S. Sumathi

    1. School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625 021, India
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Abstract

original image

The chalcones 1-(2′-hydroxy-aryl)-3-(1-indol-3-yl)-prop-2-en-1-one (3) and 1-(2′-hydroxy-aryl)-3-(2-chloroquinolin-3-yl)-prop-2-en-1-one (6) were synthesised by piperidine mediated condensation of an ethanolic solution of an o-hydroxyacetophenone (1) with corresponding heteroaryl-3-carboxaldehyde. The structures have been established on the basis of elemental (C, H, N) analysis, UV, IR, 1H NMR spectral data. The compounds and were screened for antimicrobial activities against a variety of bacterial agents. J. Heterocyclic Chem., 2010.

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