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Selective reduction of 2,4-dinitro- and 4,5-dinitroimidazole derivatives using iron dust

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A series of N-substituted 2,4-dinitroimidazoles, 4,5-dinitroimidazoles, and 2-methyl-4,5-dinitroimidazoles have been selectively reduced to the corresponding aminonitroimidazole derivatives, using iron dust in glacial acetic acid at room temperature. 2,4-Dinitroimidazoles have been reduced to the 2-amino-4-nitro-derivatives only but 4,5-dinitroimidazoles have given 4-amino-5-nitro- or 5-amino-4-nitro- derivatives depended on the structure of the N-substituent. J. Heterocyclic Chem., (2010).

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