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Article
Synthesis of 4,12-dihydro-4-oxoquino-[1,8a,8-a,b]quinoxaline-5-carboxylic acid derivatives
Article first published online: 6 APR 2009
DOI: 10.1002/jhet.5570250343
Copyright © 1988 Journal of Heterocyclic Chemistry
1943-5193/asset/cover.gif?v=1&s=bb508dac07d24df5b58b6b66a06622c926a8f7c0 "Journal of Heterocyclic Chemistry")
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How to Cite
Chu, D. T. W., Maleczka, R. E. and Nordeen, C. W. (1988), Synthesis of 4,12-dihydro-4-oxoquino-[1,8a,8-a,b]quinoxaline-5-carboxylic acid derivatives. J. Heterocyclic Chem., 25: 927–930. doi: 10.1002/jhet.5570250343
Publication History
- Issue published online: 6 APR 2009
- Article first published online: 6 APR 2009
- Manuscript Received: 1 DEC 1987
- Abstract
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- Cited By
Abstract
The synthesis and antibacterial activity of 1-substituted amino-2-fluoro-4,12-dihydro-4-oxoquino[1,8a,8-a,b]quinoxaline-5-carboxylic acid derivatives are described. The synthetic route includes a carbon homologation and two intramolecular nucleophilic displacement cyclization reactions leading to the novel 4,12-dihydro-4-oxoquino[1,8a,8-a,b]quinoxaline-5-carboxylic acid heterocycle.