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Abstract

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A series of functionalized, aryl substituted naphthyridines and quinolines has been synthesized by microwave-assisted one-pot two-component synthesis under solvent-free conditions in good yields by the reaction of a variety of aryl or heteroaryl amines and aryl vinyl ketones. A combinatorial type approach for a one-step microwave reaction has been developed where a ring-closing condensation is followed by a spontaneous aromatization to afford the functionalized aryl substituted 1,8-naphthyridines and quinolines.

Featured Compounds

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Compound Information
Molecular Weight:295.3771
Molecular Formula:C22H17N
InChIKey:KIVAAOCNLODBHE-UHFFFAOYSA-N
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Compound Information
Molecular Weight:374.273
Molecular Formula:C22H16BrN
InChIKey:VPNUHGYDEIOMDE-UHFFFAOYSA-N
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Compound Information
Molecular Weight:311.3765
Molecular Formula:C22H17NO
InChIKey:VQVXFWLQBQAHCH-UHFFFAOYSA-N
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Compound Information
Molecular Weight:390.273
Molecular Formula:C22H16BrNO
InChIKey:WPFQYZVXWGGAID-UHFFFAOYSA-N
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Compound Information
Molecular Weight:296.3651
Molecular Formula:C21H16N2
InChIKey:PRSUVKXINFOOKG-UHFFFAOYSA-N
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Compound Information
Molecular Weight:375.261
Molecular Formula:C21H15BrN2
InChIKey:NZHHOQWAQARMPB-UHFFFAOYSA-N
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Compound Information
Molecular Weight:361.235
Molecular Formula:C20H13BrN2
InChIKey:DRUBZDLKRYBBNE-UHFFFAOYSA-N
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Compound Information
Molecular Weight:440.131
Molecular Formula:C20H12Br2N2
InChIKey:WQHQCSATVGKNDT-UHFFFAOYSA-N
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Compound Information
Molecular Weight:282.3386
Molecular Formula:C20H14N2
InChIKey:YQTUGIQKFLUBRA-UHFFFAOYSA-N
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Compound Information
Molecular Weight:361.235
Molecular Formula:C20H13BrN2
InChIKey:MEIUYTQOMHPFSK-UHFFFAOYSA-N
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Compound Information
Molecular Weight:297.3532
Molecular Formula:C20H15N3
InChIKey:PYZDJEKLHZJXOK-UHFFFAOYSA-N
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Compound Information
Molecular Weight:376.249
Molecular Formula:C20H14BrN3
InChIKey:OVEAIYBQBUXIMF-UHFFFAOYSA-N
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Compound Information
Molecular Weight:395.292
Molecular Formula:C21H19BrN2O
InChIKey:GMPXJRBLQMBCQS-UHFFFAOYSA-N
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Compound Information
Molecular Weight:410.304
Molecular Formula:C22H20BrNO2
InChIKey:YISTZFDBEDTFGW-UHFFFAOYSA-N
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