Article

Synthesis of the indole core structures of conophylline

  1. Shin Ando1,
  2. Yoshinari Okamoto1,
  3. Masami Otsuka1,
  4. Kazuo Umezawa2

Article first published online: 13 MAR 2009

DOI: 10.1002/jhet.5570450638

Issue

Journal of Heterocyclic Chemistry

Journal of Heterocyclic Chemistry

Volume 45, Issue 6, pages 1803–1808, November/December 2008

Additional Information

How to Cite

Ando, S., Okamoto, Y., Otsuka, M. and Umezawa, K. (2008), Synthesis of the indole core structures of conophylline. Journal of Heterocyclic Chemistry, 45: 1803–1808. doi: 10.1002/jhet.5570450638

Author Information

  1. 1

    Faculty of Medical and Pharmaceutical Sciences, Kumamoto University 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

  2. 2

    Department of Applied Chemistry, Faculty of Science and Technology, Keio University Yokohama 223-0061, Japan

Publication History

  1. Issue published online: 13 MAR 2009
  2. Article first published online: 13 MAR 2009
  3. Manuscript Received: 19 DEC 2007

Funded by

  • Grant-in- Aid for Scientific Research. Grant Number: NO.17390030
  • Kumamoto Technology and Industry Foundation
  • Shorai Foundation for Science and Technology

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Abstract

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Conophylline is a bisindole alkaloid of unique structure that shows anti-cancer and anti-diabetic activities. Two indole core structures of conophylline, namely 6,7-dimethoxy-5-methoxymethoxy-1H-indole (1), and N-benzoyl-N-[2-(6-methoxymethoxy-2-vinyl-1H-indol-3-yl)ethyl]amine (2) has been synthesized starting with substituted benzene derivatives.

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