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Expeditious Synthesis and Single Crystal Structure of New Pyrazole-Fused 1,4-Oxazine

Authors

  • Liang-Wen Zheng,

    1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, People's Republic of China
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  • Bao-Xiang Zhao,

    Corresponding author
    1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, People's Republic of China
    • Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China

      E-mail: bxzhao@sdu.edu.cn

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  • Ying-Rui Liu

    1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, People's Republic of China
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Abstract

A series of 2,6-diphenyl-4H-pyrazolo[5,1-c][1,4]oxazin-4-ones has been synthesized via a lactonization of 1-(2-oxo-2-phenylethyl)-3-phenyl-1H-pyrazole-5-carboxylic acids in the presence of Ac2O at reflux temperature. The products were isolated by simple filtration in excellent yields and were characterized by IR, 1H-NMR, and HRMS. The molecular structure was confirmed by the X-ray crystal analysis of one compound that was prone to crystallization.

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