Cyclodextrin derivatives in GC separation of racemic mixtures of volatiles – part XII: Thick-film wide-bore columns for enantiomer GC preparation

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Abstract

Preliminary results on thick-film wide-bore (0.53mm i.d.) columns for GC preparation of pure enantiomers are described. In particular the loading capacity for several racemates of a 3μm, 30% 2,6-di-O-methyl-3-O-Pentyl-β-CD/OV1701 column and of a 2 μm, 30% 2,3-di-O-acetyl-6-O-dimethyl-t-butylyl-β-CD/PS-086 collumn were determined. Consideration is also given to the relation-ship between resolution values of two enantiomers on anayltical columns and their loading capacity and scaling-up to the corresponding micropreparative columns.

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