Capillary gas chromatographic separation of C10–C12 secondary phenylalkanes on modified cyclodextrin stationary phases

Authors

  • Ivan Špáanik,

    1. Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Radlinskéeho 9, 812 37 Bratislava, Slovakia
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  • Jáan Krupcik,

    Corresponding author
    1. Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Radlinskéeho 9, 812 37 Bratislava, Slovakia
    • Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Radlinskéeho 9, 812 37 Bratislava, Slovakia
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  • Ivan Skacáani,

    1. Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Radlinskéeho 9, 812 37 Bratislava, Slovakia
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  • Jaap De Zeeuw,

    1. Chrompack International, Kuiperweg 6, NL-4330 EA Middelburg, The Netherlands
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  • Mario Galli,

    1. MEGA, Capillary Column Labortory, Via Plinio 29, 20025 Legnano (Mi), Italy
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  • Pat Sandra

    1. Department of Organic Chemistry, Gent University, Krijgslaan 281 (S-4), B-4100 Gent, Belgium
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Abstract

The separation of isomers and enantiomers of branched C10-C12 phenylalkanes by gas chromatography on fused silica capillary columns coated with some modified β- and γ-cyclodextrins was studied. It was shown that the separation of positional isomers of C10-C12 phynylalkanes on modified cyclodextrin capillary columns is not better than that on a column coated with modified polyethylene glycol. Differences were found in the enantioselectivity of modified β- and γ-cyclodextrins for the separation of C10-C12 secondary phenylalkane enantiomers. While alkylderivatives of β-CDs resolve enantiomers of 3-phenylalkanes, alkyl derivatives of γ-CD resolve enantiomers of 2-phenylalkanes. Since shape selectivity factors of modified cyclodextrins have indicated no inclusion of the considered solutes in cyclodextrin cavities, enantioselective interactions most probably occur on the outer sphere of cyclodextrins.

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