A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor
Version of Record online: 3 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Journal of Labelled Compounds and Radiopharmaceuticals
Volume 53, Issue 1, pages 47–49, January 2010
How to Cite
Taldone, T., Zatorska, D., Kang, Y. and Chiosis, G. (2010), A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor. J Label Compd Radiopharm, 53: 47–49. doi: 10.1002/jlcr.1689
- Issue online: 8 JAN 2010
- Version of Record online: 3 DEC 2009
- Manuscript Accepted: 14 SEP 2009
- Manuscript Revised: 29 JUL 2009
- Manuscript Received: 29 MAY 2009
- deuterium labeled PU-H71;
- heat shock protein 90;
PU-H71 is a purine-scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d6-labeled PU-H71 for use as an internal standard to accurately quantitate the drug in biological matrices based on an LC-MS-MS method. PU-H71-d6 was synthesized in five steps using readily available 1,3-dibromopropane-d6 and is an important compound for the advancement of our clinical program. Copyright © 2009 John Wiley & Sons, Ltd.