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Keywords:

  • 15N-labelled oxamate;
  • 13C-labelled oxamate;
  • 14C-labelled oxamate;
  • 18O-labelled oxamate

Abstract

Since none of the available methods was suitable for the synthesis of isotopically labelled oxamate, a new procedure has been developed in our laboratory, based on the known procedures, but with substantial modifications. The method is convenient and gives reproducibly 17% yield based on KCN used. The strategy is considered suitable for labelling oxamate with 15N and 13C or 14C when starting with labelled KCN and can be easily modified for the synthesis of 18O-carbonyl-labelled oxamate. Copyright © 2011 John Wiley & Sons, Ltd.