Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide
Article first published online: 3 NOV 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Journal of Labelled Compounds and Radiopharmaceuticals
Volume 55, Issue 1, pages 1–4, January 2012
How to Cite
Pedersen, M. H. F. and Baun, M. (2012), Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide. J Label Compd Radiopharm, 55: 1–4. doi: 10.1002/jlcr.1941
- Issue published online: 25 JAN 2012
- Article first published online: 3 NOV 2011
- Manuscript Accepted: 18 SEP 2011
- Manuscript Revised: 5 SEP 2011
- Manuscript Received: 18 JUL 2011
- heterogeneous catalysis
In the interest of developing efficient methods for tritium labelling peptides, we here demonstrate the successful labelling of PACAP-38 (pituitary adenylate cyclase-activating polypeptide), a 38-mer peptide, using a synthetic diiodinated PACAP-38 precursor. In this example, we employ standard hydrogenation chemistry with the use of a heterogeneous palladium catalyst and carrier-free tritium gas on a tritium manifold system. Copyright © 2011 John Wiley & Sons, Ltd.