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Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl)butanamide) with high specific activity

Authors


Dr. Christa E. Müller, Pharmazeutisches Institut, Pharmazeutische Chemie I, An der Immenburg 4, D-53121 Bonn, Germany.

E-mail: christa.mueller@uni-bonn.de

Abstract

A method for the preparation of [³H]levetiracetam with a high specific activity of 98 Ci/mmol (3.6 TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations. Copyright © 2011 John Wiley & Sons, Ltd.

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