Production and purification of the positron emitter zinc-63


Toshimitsu Fukumura Ph.D. Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263–8555, Japan.



This study presents the production and purification of the positron emitting radionuclide 63Zn. A natural copper target was irradiated with 13.5 MeV protons, and 63Zn was purified by cation exchange chromatography using 0.05 N HCl-85% acetone as eluent. The production yield reached 1.41 ± 0.19 GBq/μA⋅h at the end of bombardment and 169 ± 30 MBq/μA·h after purification, with more than 99.9% of radionuclidic purity with copper content around 0.04 μg/g. Copyright © 2011 John Wiley & Sons, Ltd.