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Keywords:

  • Clonidine;
  • deuterium;
  • carbon-13;
  • synthesis;
  • mass spectra

Abstract

The synthesis is reported of a number of analogues of clonidine and 1,3-dimethylclonidine labelled specifically and in high isotopic purity with deuterium and carbon-13. 2,6-Dichloro[4-2H1] aniline and 2,6-dichloro-[3,4,5-2H3]Janiline were employed to prepare compounds substituted in the aromatic ring with one and three atoms of deuterium, respectively, while the use of appropriate derivatives of ethylenediamine led to products in which the imidazol idine ring was labelled with carbon-13 or deuterium.