Synthesis of clonidine and 1,3-dimethylclonidine labelled at specific positions with deuterium and carbon-13
Article first published online: 10 JUL 2006
Copyright © 1980 John Wiley & Sons, Ltd.
Journal of Labelled Compounds and Radiopharmaceuticals
Volume 17, Issue 6, pages 871–888, November/December 1980
How to Cite
Hughes, H. and Baillie, T. A. (1980), Synthesis of clonidine and 1,3-dimethylclonidine labelled at specific positions with deuterium and carbon-13. J Label Compd Radiopharm, 17: 871–888. doi: 10.1002/jlcr.2580170613
- Issue published online: 10 JUL 2006
- Article first published online: 10 JUL 2006
- Manuscript Received: 19 FEB 1979
- Boehringer Ingelheim (UK)
- mass spectra
The synthesis is reported of a number of analogues of clonidine and 1,3-dimethylclonidine labelled specifically and in high isotopic purity with deuterium and carbon-13. 2,6-Dichloro[4-2H1] aniline and 2,6-dichloro-[3,4,5-2H3]Janiline were employed to prepare compounds substituted in the aromatic ring with one and three atoms of deuterium, respectively, while the use of appropriate derivatives of ethylenediamine led to products in which the imidazol idine ring was labelled with carbon-13 or deuterium.