Dpt. Quimica, Fac. Veterinaria, Univ. Extremadura, CACERES (Espana)
Preparation of 18O-bilabelled carboxylic acids: Cinnahic and phenylpropiolic acids via styrylisoxazoles
Article first published online: 28 JUL 2006
Copyright © 1986 John Wiley & Sons, Ltd.
Journal of Labelled Compounds and Radiopharmaceuticals
Volume 23, Issue 5, pages 487–493, May 1986
How to Cite
Baracchi, A., Chimichi, S., De Sio, F., Donati, D., Nesi, R., Sartifantoni, P. and Torroba, T. (1986), Preparation of 18O-bilabelled carboxylic acids: Cinnahic and phenylpropiolic acids via styrylisoxazoles. J Label Compd Radiopharm, 23: 487–493. doi: 10.1002/jlcr.2580230505
- Issue published online: 28 JUL 2006
- Article first published online: 28 JUL 2006
- Manuscript Received: 28 NOV 1985
- Oxygen-18 and deuterium labelled compounds;
- 3-phenyl-2-propenoic and 3-phenyl-2-propynoic acids
3-Phenyl-2-propenoic (cinnamic) and 3- [2H5] -phenyl-2- propenoic 80O-bilabelled acids (2c,d) are prepared via alkaline hydrolysis of styrylisoxazoles (1a,b). The same reaction carried out on the vic-dibromocompounds (3a,b) gave the 3-phenyl-2-propynoic (phenylpropiolic) and 3-[2H5]-Phenyl-2-propynoic 18O-bilabelled acids (4c,d), respectively.