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PET radioligands for the vesicular transporters for monoamines and acetylcholine

Authors

  • Michael R. Kilbourn

    Corresponding author
    • Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA
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  • This article is published in the Journal of Labelled Compounds and Radiopharmaceuticals as a special issue on carbon-11 and fluorine-18 chemistry devoted to molecular probes for imaging the brain with PET, edited by Frédéric DOLLÉ, Service Hospitalier Frédéric Joliot, Institut d'Imagerie BioMédicale – CEA, 4 Place du Général Leclerc – F-91406 Orsay – France.

Correspondence to: Michael R. Kilbourn, Ph.D., Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.

E-mail: mkilbour@umich.edu

Abstract

The vesicular transporters for the monoamine and acetylcholine have been successfully targeted for the development of radioligands for human brain imaging. The vesicular monoamine transporter type 2 ligands are based on the structure of tetrabenazine, a known clinically used drug. In contrast, the radioligands for vesicular acetylcholine transporter are based on vesamicol, a toxic xenobiotic. The similarities and differences in the development of these two classes of radioligands are discussed. Copyright © 2013 John Wiley & Sons, Ltd.

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