Research Article

A practical laboratory route to the synthesis of trideuteriomethyl-[13C] iodide

  1. Gregory S. Coumbarides,
  2. Jason Eames*,
  3. Neluka Weerasooriya

Article first published online: 19 FEB 2003

DOI: 10.1002/jlcr.666

Issue

Journal of Labelled Compounds and Radiopharmaceuticals

Journal of Labelled Compounds and Radiopharmaceuticals

Volume 46, Issue 4, pages 291–296, 30 March 2003

Additional Information

How to Cite

Coumbarides, G. S., Eames, J. and Weerasooriya, N. (2003), A practical laboratory route to the synthesis of trideuteriomethyl-[13C] iodide. Journal of Labelled Compounds and Radiopharmaceuticals, 46: 291–296. doi: 10.1002/jlcr.666

Author Information

  1. Department of Chemistry, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

*Department of Chemistry, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

Publication History

  1. Issue published online: 19 FEB 2003
  2. Article first published online: 19 FEB 2003
  3. Manuscript Accepted: 16 SEP 2002
  4. Manuscript Revised: 13 SEP 2002
  5. Manuscript Received: 17 JUL 2002

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Keywords:

  • Deuterium;
  • Carbon-13 and Trideuterio-[13C]-methyl iodide

Abstract

A practical synthetic laboratory route for the synthesis of trideuteriomethyl-[13C] iodide (13CD3I) (from tetradeuterio-[13C]-methanol and hydriodic acid) is described. We comment on the experimental protocol, and the use of water as an ‘additive’ to improve the synthetic yield. Copyright © 2003 John Wiley & Sons, Ltd.

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