Pharmacological characterization of 18F-labeled vorozole analogs (pages 484–490)
Håkan Hall, Kayo Takahashi, Maria Erlandsson, Sergio Estrada, Pasha Razifar, Elisabeth Bergström and Bengt Långström
Article first published online: 20 NOV 2012 | DOI: 10.1002/jlcr.2982
Two 18F-labeled analogs of vorozole ([18F]FVOZ and [18F]FVOO) have been evaluated using in vitro binding and in vivo distribution studies in the rat and primate. Ex vivo and in vitro autoradiography of the rat brain showed specific binding of both ligands mainly in the amygdala, and positron emission tomography (PET) studies with [18F]FVOZ in the Rhesus monkey showed specific binding in the amygdala. This suggests that [18F]FVOZ might be a suitable tracer for the study of aromatase in vivo in human PET studies.