Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 56 Issue 2

February 2013

Volume 56, Issue 2

Pages i–iv, 31–63

  1. Cover and Masthead

    1. Top of page
    2. Cover and Masthead
    3. Research Articles
    4. Abstracts
    1. Editorial Board (pages i–iv)

      Article first published online: 25 FEB 2013 | DOI: 10.1002/jlcr.3036

  2. Research Articles

    1. Top of page
    2. Cover and Masthead
    3. Research Articles
    4. Abstracts
    1. Large-scale preparation of 13C-labeled 2-(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones (pages 31–35)

      Rodolfo A. Martinez, David R. Glass, Erick G. Ortiz, Marc A. Alvarez, Ernesto Juarez, Siegfried N. Lodwig and Clifford J. Unkefer

      Article first published online: 16 JAN 2013 | DOI: 10.1002/jlcr.2991

      Thumbnail image of graphical abstract

      We have developed two efficient synthetic routes to 2-(phenylthio)[1-13C]-, [2-13C]-, and [1,2-13C2]acetic acid and described conditions for their conversion to the corresponding ethyl esters. In addition, we have described the oxidation of 13C-labeled ethyl 2-(phenylthio)acetates to their corresponding sulfones and sulfoxides. The described 13C-isotopomers of 2-(phenylthio)acetic acid, ethyl 2-(phenylthio)acetate, ethyl 2-(phenylsulfinyl)acetate, and ethyl 2-(phenylsulfonyl)acetate are versatile, chemically stable, and nonvolatile two carbon-labeling precursors.

    2. A convenient method to produce [14C]carbon monoxide and its application to the radiosynthesis of [carboxyl-14C]celivarone, [carboxyl-14C]SSR149744 (pages 36–41)

      David M. Whitehead, Sascha Hartmann, Tenzeela Ilyas, Keith R. Taylor, Andrew D. Kohler and George J. Ellames

      Article first published online: 22 JAN 2013 | DOI: 10.1002/jlcr.3009

      Thumbnail image of graphical abstract

      [carboxyl-14C]Celivarone was synthesised from barium [14C]carbonate with overall radiochemical yields in the range 49–53%. The synthetic route involves [14C]carbonylation methodology, which both decreased the number of synthetic steps and increased the yields obtained from previous synthetic routes.

    3. A practical synthesis of [18F]FtRGD: an angiogenesis biomarker for PET (pages 42–49)

      Romain Bejot, Julian Goggi, Shebbrin S. Moonshi and Edward G. Robins

      Article first published online: 30 JAN 2013 | DOI: 10.1002/jlcr.3019

      Thumbnail image of graphical abstract

      A two-step, two-pot, and chemoselective strategy was developed for the radiolabeling of the c(RGDyK) peptide. Via nucleophilic detagging and fluorous solid-phase extraction, we obtain 2-[18F]fluoroethyl azide that is further used in the CuAAC conjugation reaction to prepare the 2-[18F]fluoroethyl-triazolyl conjugated c(RGDyK) peptide: [18F]FtRGD. [18F]FtRGD displayed a good affinity and selectivity for integrins both in vitro and in vivo, and proved valuable for preclinical positron emission tomography imaging of integrin expression.

  3. Abstracts

    1. Top of page
    2. Cover and Masthead
    3. Research Articles
    4. Abstracts
    1. Abstracts of the 21st International Isotope Society (UK group) symposium: synthesis and applications of labelled compounds 2012 (pages 50–63)

      Erik Årstad, Adam Badar, Andrew Baxter, John F. Bower, Karl M. Cable, Michael A. Carroll, Melanie Y. T. Chan, Michael Charlton, Martin Christlieb, Bart Cornelissen, Liam R. Cox, Ben Davis, Jonathan R. Dilworth, Ethaar El-Emir, George J. Ellames, Eva Galante, Neil Geach, Antony D. Gee, Véronique Gouverneur, Thomas J. Gregson, David Hendry, Rebekka Hueting, Kamila Hussien, Tenzeela Ilyas, Daniel D. Jenkins, Veerle Kersemans, Eric Knagg, Matthias Koepp, Andrew D. Kohler, Joel A. Krauser, Guillaume G. Launay, William J. S. Lockley, Mark F. Lythgoe, Daniel P. Manthorpe, Andrew McEwen, Ruth J. Muschel, Mark F. Oldfield, Jan Passchier, R. Barbara Pedley, Vineeth Rajkumar, Christopher D. Reed, Mathew Robson, Stephen J. Roe, Jim J. Ryan, Kerstin Sander, Nick Shipley, Sean C. Smart, Neil Smith, Daniel W. Spurr, Keith R. Taylor, Matthew Tredwell, David M. Whitehead, Geoffrey Woolley and Ran Yan

      Article first published online: 25 FEB 2013 | DOI: 10.1002/jlcr.3015

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