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Original Research
Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging
Article first published online: 23 JUL 2002
DOI: 10.1002/jmri.10140
Copyright © 2002 Wiley-Liss, Inc.
1522-2586/asset/cover.gif?v=1&s=7744bbc5c5ee23bd9677f861606033d1d6742e48 "Journal of Magnetic Resonance Imaging")
Additional Information
How to Cite
Guo, Y., Cai, Y.-Q., Cai, Z.-L., Gao, Y.-G., An, N.-Y., Ma, L., Mahankali, S. and Gao, J.-H. (2002), Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging. J. Magn. Reson. Imaging, 16: 172–178. doi: 10.1002/jmri.10140
Publication History
- Issue published online: 23 JUL 2002
- Article first published online: 23 JUL 2002
- Manuscript Accepted: 25 MAR 2002
- Manuscript Received: 2 NOV 2001
- Abstract
- Article
- References
- Cited By
Keywords:
- breast neoplasm, diagnosis;
- magnetic resonance (MR), diffusion-weighted imaging;
- apparent diffusion coefficient;
- tumor cellularity;
- pathology
Abstract
Purpose
To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions.
Materials and Methods
Fifty-two female subjects (mean age = 58 years, age range = 25–75 years) with histopathologically proven breast lesions underwent DWI of the breasts with a single-shot echo-planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated.
Results
The ADCs varied substantially between benign breast lesions ((1.57 ± 0.23) × 10−3 mm2/second) and malignant breast lesions ((0.97 ± 0.20) × 10−3 mm2/second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P < 0.01, r = −0.542).
Conclusion
The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors. J. Magn. Reson. Imaging 2002;16:172–178. © 2002 Wiley-Liss, Inc.