Serial quantitative diffusion tensor MRI of the premature brain: Development in newborns with and without injury
Article first published online: 25 NOV 2002
Copyright © 2002 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 16, Issue 6, pages 621–632, December 2002
How to Cite
Miller, S. P., Vigneron, D. B., Henry, R. G., Bohland, M. A., Ceppi-Cozzio, C., Hoffman, C., Newton, N., Partridge, J. C., Ferriero, D. M. and Barkovich, A. J. (2002), Serial quantitative diffusion tensor MRI of the premature brain: Development in newborns with and without injury. J. Magn. Reson. Imaging, 16: 621–632. doi: 10.1002/jmri.10205
- Issue published online: 25 NOV 2002
- Article first published online: 25 NOV 2002
- Manuscript Accepted: 24 JUL 2002
- Manuscript Received: 25 MAR 2002
- National Institutes of Health. Grant Numbers: NS40117, NS35902, RR01271, NS40382
- Canadian Institutes of Health Research Clinician Scientist Program
- Glaser Pediatric Research Network Fellowship Award
- diffusion tensor imaging;
- periventricular leukomalacia;
- brain development;
- magnetic resonance imaging
To determine the change over time of the apparent diffusion coefficient (ADC) and relative anisotropy of cerebral water in a cohort of premature newborns serially studied near birth and again near term.
Materials and Methods
Newborns were classified as normal (N = 11), minimal white matter injury (N = 7), or moderate white matter injury (N = 5).
ADC decreased significantly with age in all brain regions in newborns classified as normal and those with minimal white matter injury. ADC increased with age or failed to decline in widespread areas of white matter in newborns with moderate white matter injury. Anisotropy increased with age in all white matter regions in newborns classified as normal. Anisotropy did not increase in frontal white matter in those with minimal white matter injury, and in widespread white matter areas in those with moderate white matter injury.
This study demonstrates that serial diffusion tensor magnetic resonance imaging scans of premature newborns can detect differences in white matter maturation in infants with and without white matter injury. J. Magn. Reson. Imaging 2002;16:621–632. © 2002 Wiley-Liss, Inc.