Lipid content in the musculature of the lower leg assessed by fat selective MRI: Intra- and interindividual differences and correlation with anthropometric and metabolic data
Article first published online: 19 FEB 2003
Copyright © 2003 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 17, Issue 3, pages 350–357, March 2003
How to Cite
Machann, J., Bachmann, O. P., Brechtel, K., Dahl, D. B., Wietek, B., Klumpp, B., Häring, H.-U., Claussen, C. D., Jacob, S. and Schick, F. (2003), Lipid content in the musculature of the lower leg assessed by fat selective MRI: Intra- and interindividual differences and correlation with anthropometric and metabolic data. J. Magn. Reson. Imaging, 17: 350–357. doi: 10.1002/jmri.10255
- Issue published online: 19 FEB 2003
- Article first published online: 19 FEB 2003
- Manuscript Accepted: 18 NOV 2002
- Manuscript Received: 28 MAY 2002
- Deutsche Forschungsgemeinschaft. Grant Number: DFG #JA-1005/1
- Federal Ministry of Education and Research. Grant Number: Fö. 01KS9602
- Interdisciplinary Center of Clinical Research Tübingen (IZKF)
- fat-selective MRI;
- skeletal muscle;
- muscular lipids;
- type 2 diabetes;
- lipid content
To assess the muscular lipid content (LC) in different muscle groups of the lower leg by a magnetic resonance imaging technique working with chemical shift selective excitation, and comparison with anthropometric and metabolic data.
Materials and Methods
Examinations were performed in 67 volunteers (54 male/13 female, age 29 ± seven years) on a 1.5 T whole body imager, applying a highly selective spectral-spatial technique for fat selective MRI. LC was measured in six calf muscles and correlated with body mass index (BMI), percent body fat (PFAT), and insulin sensitivity (IS) of the subjects.
Mean muscular LC of all subjects was between 2.0% (Tibialis posterior [TP]) and 3.8% (Peroneus muscles) with female subjects showing a significantly higher LC in all muscle groups (P < 0.05 each). LCs correlated moderately with BMI (R between 0.39 [TP] and 0.53 [GM]) and with PFAT (R between 0.38 [TP] and 0.62 [GM]). Insulin-resistant subjects showed slightly but not significantly increased LC compared to insulin-sensitive subjects in BMI-matched subgroups.
The fat-selective MRI technique allows a reliable non-invasive measure of muscular lipids – even in muscle groups with inherent low LC – within a relatively short measurement time of about three minutes. The presented data reveal interesting interrelationships between LC and anthropometric and metabolic data, and therefore provide new insight into muscular fat metabolism. J. Magn. Reson. Imaging 2003;17:350–357. © 2003 Wiley-Liss, Inc.