A reproducible repositioning method for serial magnetic resonance imaging studies of the brain in treatment trials for multiple sclerosis



Serial MRI is an important measure of disease progression in evaluating the treatment of multiple sclerosis (MS). Accurate comparisons of scans for lesion activity and lesion volume require precise repositioning of patients. A simple, reproducible repositioning method is described. In a multicenter treatment trial of MS using β-interferon-1b, this method has been successful, with only 1.1% of scans being rejected because of poor repositioning.