Original Research

Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics

  1. Geoffrey J. M. Parker BSc*,
  2. John Suckling PhD,
  3. Steven F. Tanner PhD,
  4. Anwar R. Padhani Mrcp, Frcr,
  5. Patrick B. Revell Bsc, Dcrr,
  6. Janet E. Husband Frcp, Frcr,
  7. Martin O. Leach Phd, Flnstp, Fipemb

Article first published online: 17 NOV 2005

DOI: 10.1002/jmri.1880070318

Issue

Journal of Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Volume 7, Issue 3, pages 564–574, May/June 1997

Additional Information

How to Cite

Parker, G. J. M., Suckling, J., Tanner, S. F., Padhani, A. R., Revell, P. B., Husband, J. E. and Leach, M. O. (1997), Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics. Journal of Magnetic Resonance Imaging, 7: 564–574. doi: 10.1002/jmri.1880070318

Author Information

  1. Cancer Research Campaign Clinical Magnetic Resonance Research Group, the Institute of Cancer Research and the Royal Marsden National Health Service Trust, Sutton, Surrey, SM2 5PT, United Kingdom

*Cancer Research Campaign Clinical Magnetic Resonance Research Group, the Institute of Cancer Research and the Royal Marsden National Health Service Trust, Sutton, Surrey, SM2 5PT, United Kingdom

Publication History

  1. Issue published online: 17 NOV 2005
  2. Article first published online: 17 NOV 2005
  3. Manuscript Accepted: 18 FEB 1997
  4. Manuscript Received: 12 SEP 1996

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Keywords:

  • Contrast enhancement;
  • False color;
  • Parametric images;
  • Pharmacokinetics;
  • Gd-DTPA

Abstract

This paper describes a measurement protocol for acquiring quantitative dynamic MRI data and novel analysis and display software (Magnetic Resonance Imaging Workbench (MRIW)). Proton density-weighted and T1-weighted two-dimensional gradient echo images are used to quantify tissue contrast agent concentration. The dynamic studies last approximately 7 minutes, with 10-second temporal resolution. Analyses of signal and concentration changes with time are performed, allowing capillary permeability-surface area product, tissue leakage space, enhancement onset time, mean enhancement gradient and maximum enhancement level to be mapped as false-color parametric overlays registered with anatomic images. Quantification of permeability and leakage space provides a method for comparing physiology in patients between visits or for intersite comparisons.

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