Oral presentation at the ISMRM meeting 2002, Honolulu, Hawaii
In vivo detection of hemorrhage in human atherosclerotic plaques with magnetic resonance imaging†
Article first published online: 21 JUN 2004
Copyright © 2004 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 20, Issue 1, pages 105–110, July 2004
How to Cite
Cappendijk, V. C., Cleutjens, K. B.J.M., Heeneman, S., Schurink, G. W. H., Welten, R. J.Th.J., Kessels, A. G.H., van Suylen, R. J., Daemen, M. J.A.P., van Engelshoven, J. M.A. and Kooi, M. E. (2004), In vivo detection of hemorrhage in human atherosclerotic plaques with magnetic resonance imaging. J. Magn. Reson. Imaging, 20: 105–110. doi: 10.1002/jmri.20060
- Issue published online: 21 JUN 2004
- Article first published online: 21 JUN 2004
- Manuscript Accepted: 30 JAN 2004
- Manuscript Received: 24 JUL 2003
- Dutch Heart Foundation. Grant Number: 2000.173
- vessel wall imaging;
- vulnerable plaque;
To investigate the performance of high-resolution T1-weighted (T1w) turbo field echo (TFE) magnetic resonance imaging (MRI) for the identification of the high-risk component intraplaque hemorrhage, which is described in the literature as a troublesome component to detect.
Materials and Methods
An MRI scan was performed preoperatively on 11 patients who underwent carotid endarterectomy because of symptomatic carotid disease with a stenosis larger than 70%. A commonly used double inversion recovery (DIR) T1w turbo spin echo (TSE) served as the T1w control for the T1w TFE pulse sequence. The MR images were matched slice by slice with histology, and the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the MR images were calculated. Additionally, two readers, who were blinded for the histological results, independently assessed the MR slices concerning the presence of intraplaque hemorrhage.
More than 80% of the histological proven intraplaque hemorrhage could be detected using the TFE sequence with a high interobserver agreement (Kappa = 0.73). The TFE sequence proved to be superior to the TSE sequence concerning SNR and CNR, but also in the qualitative detection of intraplaque hemorrhage. The false positive TFE results contained fibrous tissue and were all located outside the main plaque area.
The present study shows that in vivo high-resolution T1w TFE MRI can identify the high-risk component intraplaque hemorrhage with a high detection rate in patients with symptomatic carotid disease. Larger clinical trials are warranted to investigate whether this technique can identify patients at risk for an ischemic attack. J. Magn. Reson. Imaging 2004;20:105–110. © 2004 Wiley-Liss, Inc.