Whole-body T1 mapping improves the definition of adipose tissue: Consequences for automated image analysis
Article first published online: 19 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 24, Issue 2, pages 394–401, August 2006
How to Cite
Kullberg, J., Angelhed, J.-E., Lönn, L., Brandberg, J., Ahlström, H., Frimmel, H. and Johansson, L. (2006), Whole-body T1 mapping improves the definition of adipose tissue: Consequences for automated image analysis. J. Magn. Reson. Imaging, 24: 394–401. doi: 10.1002/jmri.20644
- Issue published online: 17 JUL 2006
- Article first published online: 19 JUN 2006
- Manuscript Accepted: 27 APR 2006
- Manuscript Received: 12 JUL 2005
- Swedish Research Council. Grant Number: K2003-71X-06676-21A
- magnetic resonance imaging;
- body composition;
- T1 mapping;
- adipose tissue;
- automatic segmentation
To determine whether a whole-body T1-mapping acquisition method improves the definition of adipose tissue (AT) and simplifies automated AT segmentation compared to an image-based method.
Materials and Methods
The study included 10 subjects. Two whole-body volumes were acquired from each subject using two different flip angles. Whole-body T1 maps were calculated from each pair of whole-body volumes. AT was automatically segmented from the T1 maps and from the original image slices. The results were evaluated using manually segmented slices as reference.
The T1-mapping method segmented more of the reference AT than the image-based method, with mean values (standard deviations (SDs)) of 87.7(5.1)% and 81.1(5.2)%, respectively. Compared to the image-based method, the T1-mapping method gives better histogram separation of AT in whole-body volumes. The suggested method also provides an output with smaller in-slice AT intensity variations.
The T1-mapping method improves the definition of AT. T1-based analysis is superior to analysis based on the original images, and allows fully automated and accurate whole-body AT segmentation. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.