SEARCH

SEARCH BY CITATION

Keywords:

  • Alzheimer's disease;
  • amyloid-β;
  • T1rho;
  • spin-lock imaging;
  • MRI

Abstract

Purpose

To demonstrate an MRI method for directly visualizing amyloid-β (Aβ) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.

Materials and Methods

We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T via quantitative relaxometric maps.

Results

A significant decrease in T was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T and the age of the animals.

Conclusion

T relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.