In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
Article first published online: 11 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 24, Issue 5, pages 1011–1017, November 2006
How to Cite
Borthakur, A., Gur, T., Wheaton, A. J., Corbo, M., Trojanowski, J. Q., Lee, V. M.-Y. and Reddy, R. (2006), In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. J. Magn. Reson. Imaging, 24: 1011–1017. doi: 10.1002/jmri.20751
- Issue published online: 20 OCT 2006
- Article first published online: 11 OCT 2006
- Manuscript Accepted: 28 JUL 2006
- Manuscript Received: 4 NOV 2005
- MMRRCC, an NIH regional resource. Grant Number: NIH RR02305
- Center for Neurodegenerative Disease Research, an NIH-funded Alzheimer's Disease Center
- Alzheimer's disease;
- spin-lock imaging;
To demonstrate an MRI method for directly visualizing amyloid-β (Aβ) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1ρ relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.
Materials and Methods
We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1ρ via quantitative relaxometric maps.
A significant decrease in T1ρ was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1ρ and the age of the animals.
T1ρ relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.