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In vivo measurement of plaque burden in a mouse model of Alzheimer's disease

Authors

  • Arijitt Borthakur PhD,

    Corresponding author
    1. Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    • Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104-6100
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  • Tamar Gur BS,

    1. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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  • Andrew J. Wheaton PhD,

    1. Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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  • Matthew Corbo BS,

    1. Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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  • John Q. Trojanowski MD, PhD,

    1. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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  • Virginia M.-Y. Lee PhD,

    1. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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  • Ravinder Reddy PhD

    1. Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Abstract

Purpose

To demonstrate an MRI method for directly visualizing amyloid-β (Aβ) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.

Materials and Methods

We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T via quantitative relaxometric maps.

Results

A significant decrease in T was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T and the age of the animals.

Conclusion

T relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.

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