In vivo brain edema classification: New insight offered by large b-value diffusion-weighted MR imaging

Authors

  • Attila Schwarcz MD, PhD,

    Corresponding author
    1. Department of Neurosurgery, University of Pécs, Pécs, Hungary
    2. Pécs Diagnostic Institute, Pécs, Hungary
    • Department of Neurosurgery, University of Pécs, Rét utca 2, H-7624 Pécs, Hungary
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  • Zsuzsa Ursprung MD,

    1. Pécs Diagnostic Institute, Pécs, Hungary
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  • Zoltan Berente PhD,

    1. Department of Biochemistry, University of Pécs, Pécs, Hungary
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  • Peter Bogner MD, PhD,

    1. Institute of Diagnostic Imaging and Radiation Oncology, University of Kaposvár, Kaposvár, Hungary
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  • Gyula Kotek MSc,

    1. Institute of Diagnostic Imaging and Radiation Oncology, University of Kaposvár, Kaposvár, Hungary
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  • Philippe Meric PhD,

    1. Laboratoire de Resonance Magnetique Nucleaire (RMN) Biologique, Institut de Chimie des Substances Naturelles (ICSN), Centre national de la recherche scientifique (CNRS), Gif-sur-Yvette, France
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  • Brigitte Gillet PhD,

    1. Laboratoire de Resonance Magnetique Nucleaire (RMN) Biologique, Institut de Chimie des Substances Naturelles (ICSN), Centre national de la recherche scientifique (CNRS), Gif-sur-Yvette, France
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  • Jean-Claude Beloeil PhD,

    1. Laboratoire de Resonance Magnetique Nucleaire (RMN) Biologique, Institut de Chimie des Substances Naturelles (ICSN), Centre national de la recherche scientifique (CNRS), Gif-sur-Yvette, France
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  • Tamás Dóczi MD, DSc

    1. Department of Neurosurgery, University of Pécs, Pécs, Hungary
    2. Pécs Diagnostic Institute, Pécs, Hungary
    3. Neurosurgical Research Group of the Hungarian Academy of Sciences, Pécs, Hungary
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Abstract

Purpose

To assess the role of large b-value diffusion weighted imaging (DWI) in the characterization of the physicochemical properties of the water in brain edema under experimental and clinical conditions.

Materials and Methods

Vasogenic brain edema was induced in mice by means of cold injury. A total of 17 patients with extensive peritumoral brain edema were also investigated. The longitudinal relaxation time (T1) and apparent diffusion coefficient (D) were measured in the edematous area both in humans and in mice. D was calculated by using both mono- (Dmono) and biexponential (Dfast and Dslow) approaches in the low and overall range of b-values, respectively. The D values were correlated with the T1 values.

Results

A strong linear correlation was found between T1 and Dmono in vasogenic brain edema, both in humans and in mice. After breakdown of Dmono into fast and slow diffusing components, only Dfast exhibited a strong correlation with T1; Dslow was unchanged in vasogenic brain edema.

Conclusion

Large b-value DWI can furnish a detailed characterization of vasogenic brain edema, and may provide a quantitative approach for the differentiation of edema types on the basis of the physicochemical properties of the water molecules. Application of the DWI method may permit prediction and follow-up of the effects of antiedematous therapy. J. Magn. Reson. Imaging 2007. © 2006 Wiley-Liss, Inc.

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