Janet Kuhlman owns stock in General Electric.
Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI
Article first published online: 8 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 26, Issue 3, pages 630–636, September 2007
How to Cite
Holmes, J. H., Korosec, F. R., Du, J., O'Halloran, R. L., Sorkness, R. L., Grist, T. M., Kuhlman, J. E. and Fain, S. B. (2007), Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI. J. Magn. Reson. Imaging, 26: 630–636. doi: 10.1002/jmri.20965
- Issue published online: 29 AUG 2007
- Article first published online: 8 AUG 2007
- Manuscript Accepted: 25 JAN 2007
- Manuscript Received: 22 JUN 2006
- National Institutes of Health. Grant Numbers: 2T32-CA09206-26, 2P50-HL056396-06
- Sandler Program for Asthma Research
- GE Healthcare
- gas trapping;
- hyperpolarized helium-3;
To image respiratory dynamics and three-dimensional (3D) ventilation during inhalation, breath-hold, and exhalation for evaluation of obstructive lung disease using a single dose of hyperpolarized (HP) He-3 during MRI.
Materials and Methods
A single 2D-3D projections inside Z encoding (PRIZE)-2D acquisition was performed that consisted of a rapid 2D radial acquisition phase during inhalation of the HP He-3, a 3D acquisition phase during a breath-hold interval, and finally the same 2D radial acquisition during a forced exhalation maneuver followed by tidal breathing. The 3D PRIZE acquisition was comprised of radial sampling in the coronal plane and Fourier encoding in the patient's anterior–posterior direction. Nine patients with mild/moderate to severe asthma were studied (two individuals were studied twice) using this technique.
Breath-hold and dynamic imaging results showed physiological abnormalities and were compared with results from standard spirometry, body plethysmography, and computed tomography (CT). Dynamic images depicted regions of differential gas clearance and trapping observed during and after forced exhalation that were corroborated as regions of air trapping on CT imaging.
The 2D-3D PRIZE-2D acquisition allowed for 3D depiction of ventilation during a breath-hold, as well as detection of gas trapping. Imaging results were confirmed with spirometry, body plethysmography, and CT. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.