T2 relaxometry of normal pediatric brain development
Article first published online: 22 JAN 2009
Copyright © 2009 Wiley-Liss, Inc.
Journal of Magnetic Resonance Imaging
Volume 29, Issue 2, pages 258–267, February 2009
How to Cite
Leppert, I. R., Almli, C. R., McKinstry, R. C., Mulkern, R. V., Pierpaoli, C., Rivkin, M. J. and Pike, G. B. (2009), T2 relaxometry of normal pediatric brain development. J. Magn. Reson. Imaging, 29: 258–267. doi: 10.1002/jmri.21646
- Issue published online: 22 JAN 2009
- Article first published online: 22 JAN 2009
- Manuscript Accepted: 7 OCT 2008
- Manuscript Received: 3 OCT 2007
- National Institute of Child Health and Human Development. Grant Number: N01-HD02-3343
- National Institute of Mental Health. Grant Number: N01-MH9-0002
- National Institute of Neurological Disorders and Stroke. Grant Numbers: N01-NS-9-2314, N01-NS-9-2315, N01-NS-9-2316, N01-NS-9-2317, N01-NS-9-2319, N01-NS-9-2320
- National Institute on Drug Abuse
- NIH Neuroscience Blueprint
- T2 relaxometry;
- brain development;
To establish normal age-related changes in the magnetic resonance (MR) T2 relaxation time constants of brain using data collected as part of the National Institutes of Health (NIH) MRI Study of Normal Brain Development.
Materials and Methods
This multicenter study of normal brain and behavior development provides both longitudinal and cross-sectional data, and has enabled us to investigate T2 evolution in several brain regions in healthy children within the age range of birth through 4 years 5 months. Due to the multicenter nature of the study and the extended period of data collection, periodically scanned inanimate and human phantoms were used to assess intra- and intersite variability.
The main finding of this work, based on over 340 scans, is the identification and parameterization of the monoexponential evolution of T2 from birth through 4 years 5 months of age in various brain structures.
The exponentially decaying T2 behavior is believed to reflect the rapid changes in water content as well as myelination during brain development. The data will become publicly available as part of a normative pediatric MRI and clinical/behavioral database, thereby providing a basis for comparison in studies assessing normal brain development, and studies of deviations due to various neurological, neuropsychiatric, and developmental disorders. J. Magn. Reson. Imaging 2009;29:258–267. © 2009 Wiley-Liss, Inc.