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Original Research
Clinical correlations of brain lesion distribution in multiple sclerosis
Article first published online: 20 MAR 2009
DOI: 10.1002/jmri.21679
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Vellinga, M., Geurts, J., Rostrup, E., Uitdehaag, B., Polman, C., Barkhof, F. and Vrenken, H. (2009), Clinical correlations of brain lesion distribution in multiple sclerosis. Journal of Magnetic Resonance Imaging, 29: 768–773. doi: 10.1002/jmri.21679
Publication History
- Issue published online: 20 MAR 2009
- Article first published online: 20 MAR 2009
- Manuscript Accepted: 3 NOV 2008
- Manuscript Received: 15 AUG 2008
Funded by
- Dutch MS Research Foundation, Voorschoten, the Netherlands. Grant Numbers: 02-358b, 05-566 MS
- Abstract
- Article
- References
- Cited By
Keywords:
- multiple sclerosis;
- lesion burden;
- lesion distribution;
- voxelwise;
- imaging
Abstract
Purpose
To explore relations between spatial distribution of multiple sclerosis (MS) lesions, and disability. In MS, the presence of asymptomatic brain lesions challenges the prediction of disability based on conventional brain MRI. Hypothesizing that symptomatology may partly be determined by lesion location, this retrospective study explored relations between lesion location and disability using voxelwise analyses in standard space.
Materials and Methods
Using nonparametric permutation-based statistics, voxelwise lesion probability on T2 lesion masks was related to expanded disability status scale (EDSS) and MS functional composite (MSFC) subdomain scores and demographic characteristics of 325 MS patients. To identify statistically significant locations, a cluster-forming threshold of 3.1 was used.
Results
In clusters in the periventricular region, lesion probability correlated significantly (P < 0.001) with disability and disease duration, and was higher in progressive than in relapsing disease. When controlled for lesion load (LL), no significant clusters survived. Presence and number of spinal cord lesions did not correlate with lesion probability in any location, and did not influence correlations with disability when included in its analyses.
Conclusion
Periventricular lesions were related to disability. LL influenced relations between disability and lesion probability throughout the brain, suggesting interplay between lesional burden and its location in determining disability in MS. J. Magn. Reson. Imaging 2009;29:768–773. © 2009 Wiley-Liss, Inc.